IL1B and Cognitive impairment: Previous reports found a negative correlation between IL1β levels and cognitive impairment levels, indicating that activated microglia and complement systems, along with increased formation of cytokines and chemokines, were involved in AD progression (Yasojima et al., 1999; Cagnin et al., 2001; Yasutake et al., 2006; Bonotis et al., 2008; Swardfager et al., 2010; Italiani et al., 2018; Baik et al., 2019).