White matter hyperintensities (WMH), which are related to a synergy between IL1β and injury response, could be induced by endothelial cell activation, inflammation, and ischemic injury of the brain, as well as aging and dementia (Origlia et al., 2014; Swardfager et al., 2017). This evidence concerns the gene IL1B and Hyperintensity of cerebral white matter on MRI.