Last but not least, TBTDC NP-PDT attenuated IMQ-induced up-regulation of inflammatory cytokines, including TGF-β1, IL-1β, IL-17, IL-23, TNF-α, IFN-γ, IL-6, and IL-22, which are important proinflammatory cytokines involved in psoriasis pathogenesis in the skin lesions of mice. This evidence concerns the gene TNF and psoriasis.