Given that intravitreal injections of PEDF protein, 17-mer or H105A peptides elevate anti-apoptotic BCL-2 and attenuate pro-apoptotic BAX levels in photoreceptors of retinal degeneration models such as the rd1 mouse and RCS rat (30,36), we hypothesized that these peptides delivered via eye drops would similarly regulate BCL-2 and BAX proteins to prevent cell death in rd10 and rd10/Serpinf1−/− retinas. Here, BCL2 is linked to retinal degeneration.