TongLuoYiShen formula consists of ten Chinese herbs, which can enhance the mRNA expression of Peroxisome proliferator-activated receptor-γ coactivator-1-α (PGC-1α), mitochondrial transcription factor A, restore the mitochondrial membrane potential, and promote mitochondrial biosynthesis in DN rats (65). This evidence concerns the gene PPARGC1A and liver dysplastic nodule.