Studies have shown that Danggui Buxue decoction can elevate the levels of PGC-1α, MnSOD mRNA and protein expression, reduce the levels of NLRP3, IL-1β mRNA and protein expression improve the mitochondrial dysfunction of podocytes in DN rats, alleviate oxidative stress, mitigate the inflammatory response, and slow down the progression of DN (63). Here, PPARGC1A is linked to liver dysplastic nodule.