Specifically, the analysis identified AGE-RAGE signaling pathway in diabetic complications, alcoholic liver disease, pertussis, antifolate resistance, amoebiasis, insulin resistance, human cytomegalovirus infection, legionellosis, inflammatory bowel disease, adipocytokine signaling pathway, tuberculosis, rheumatoid arthritis, IL-17 signaling pathway, and lipid and atherosclerosis (Figure 6). This evidence concerns the gene RENBP and legionellosis.