The up-regulation of TP53 and its associated genes, including TP53INP1, TP53I3, BAX, CDKN1A, and GDF15, in response to UM1 treatment, indicate the involvement of the p53 pathway in mediating the anti-proliferative effects of UM1 in CRC cells. The gene discussed is TP53I3; the disease is colorectal carcinoma.