TP53 and familial pancreatic carcinoma: Recent studies have reported the involvement of MEG3 in modulating various signaling pathways, including the PI3K/AKT/Bcl-2/Bax/Cyclin D1/p53 and PI3K/AKT/Bcl-2/Bax/P21 to suppress tumor growth in cervical cancer and pancreatic cancer, respectively [76].