Additionally, MYC has been identified to regulate Yorkie (Yki), the unique Drosophila ortholog of YAP/TAZ, a component of the Hippo tumor suppressor pathway, in a feed-back mechanism that restrains the growth of the imaginal discs (Neto-Silva et al., 2010; Ziosi et al., 2010). This evidence concerns the gene YAP1 and neoplasm.