TRPC4 and heart failure: Mutations in the TRPC4 gene have been associated with atrial fibrillation, Brugada syndrome, and long QT syndrome, whereas TRPC5 has been linked to the development of cardiac hypertrophy and heart failure, as well as pulmonary hypertension (Watanabe et al., 2008; Camacho et al., 2015; Lüscher, 2015; Du et al., 2021).