In the brain, it is involved in the pathogenesis of Alzheimer’s disease, where Aβ peptides, which are linked to the development of Alzheimer’s disease, correlate with TRPC3-dependent calcium influx, leading to neurotoxicity (Montecinos-Oliva et al., 2014; Wang L. et al., 2017). Here, TRPC3 is linked to early-onset autosomal dominant Alzheimer disease.