The most important role of TRPM6 is related to the homeostasis of systemic Mg2+ homeostasis, where different mutations and dysregulation of its activity have been widely reported in patients with different forms of hypomagnesemia (Schlingmann et al., 2002; Chubanov et al., 2007; Lainez et al., 2014) while also being important for the correct functioning of colonic epithelial cells (Luongo et al., 2018). This evidence concerns the gene TRPM6 and familial primary hypomagnesemia.