TRPC5 is predominantly expressed in the renal system and has been linked to the pathogenesis of several renal diseases, including focal segmental glomerulosclerosis (FSGS), diabetic nephropathy, and polycystic kidney disease (Zhou et al., 2017; Yu et al., 2019; Walsh et al., 2021). The gene discussed is TRPC5; the disease is focal segmental glomerulosclerosis.