Interestingly, two other factors named TRP channel–associated factors (TCAFs) have been described as interactors of TRPM8 that regulate its trafficking but with opposite effects on TRPM8 gating properties, with TCAF1 decreasing its activity and tumoral properties of prostate cancer cells and TCAF2 increasing it along with also promoting migration of prostate cancer cells (Gkika et al., 2015). Here, TCAF2 is linked to Familial prostate cancer.