HCV: hepatitis C virus; AFP: alpha-fetoprotein; CR: complete response; PD: progressive disease; DCP: des-γ-carboxy prothrombin; MVI: macrovascular invasion; EHM: extrahepatic metastasis; BCLC: Barcelona clinic liver cancer; M: multiple (>7); SD: stable disease; PR: partial response. Here, AFP is linked to liver cancer.