RHOA and liver disorder: Additionally, portal hypertension is also related to HSCs contraction, which is mainly due to factors such as endothelin and catecholamines acting on G protein-coupled receptors (GPCRs) or the RhoA/Rho kinase pathway, inhibiting myosin light chain phosphatase (MLCP) to further constrict HSCs, thus leading to hepatic sinusoidal stenosis and inducing portal hypertension (Iwakiri and Trebicka, 2021).