Additionally, multiple signaling pathways, including Src/extracellular regulated protein kinases/drosophila mothers against decapentaplegic homolog 3 (Src/ERK/Smad3) (Huang Y. et al., 2023), Sirt1/Notch (Sun et al., 2022), ferroptosis (Huang et al., 2022), and phosphatase and tensin homolog (Geng et al., 2020) are all involved in the activation of HSCs and hepatic fibrosis. The gene discussed is SRC; the disease is Hepatic fibrosis.