On the other hand, METTL3-m6A inhibited the stability of the TTC4 gene, further inhibiting the mitochondrial damage occurring in the HSP70/ROS/NLRP3/Caspase-1 signaling pathway, and reduced the levels of inflammatory factors such as IL-1β, IL-6, thus reducing the inflammation and scorched death of macrophages in the ALI mouse model (Chen et al., 2023). Here, METTL3 is linked to acute respiratory distress syndrome.