IL12B and asthma: In studies of lung tissue from asthmatic mice, H3K27me3 demethylation was found to regulate the contractile function and migratory reproduction function of airway smooth muscle in human asthma disease, as well as inhibit the expression of inflammatory factors IL-6 and IL-12B, which are involved in the regulation of the cellular inflammatory response as well as the development of asthma (Yu et al., 2018).