In related studies, it was found that in the ALI mouse model, METTL3-m6A mediated the expression of apolipoprotein C3 (ApoC3) mRNA in macrophages and promoted the activation of NLRP3 inflammatory vesicles, which led to macrophage pyroptosis and the release of inflammatory factors such as IL-1β, thus exacerbating the lung injury (Pu et al., 2024). The gene discussed is APOC3; the disease is acute respiratory distress syndrome.