CircN4bp1 mRNA may be upregulated in sepsis-induced acute respiratory distress syndrome macrophages with modification of METTL3-m6A, which further promotes M1 macrophage activation but inhibits M2 macrophage polarization through the CircN4bp1-miR-138–5p/EZH2 axis (Zhao et al., 2021). This evidence concerns the gene METTL3 and Sepsis.