In a mouse model of sepsis, NETs induced iron death in alveolar epithelial cells through activation of METTL3-m6A modification, a pathway that contributes to lung injury and systemic inflammation by promoting iron death via the NETs/p300/H3K27ac/METTL3-m6A/IGF2BP2-m6A/HIF-1α/GPX4/ROS pathway (Zhang et al., 2023). The gene discussed is GPX4; the disease is Sepsis.