An animal study showed that YTHDF2, which is upregulated in NK cells that are activated by cytokines or viral infection, maintained NK cell homeostasis and terminal maturation, regulated NK cell trafficking, and promoted the intrinsic function of NK cells through the formation of a STAT5-YTHDF2–positive feedback loop (Ma et al., 2021). This evidence concerns the gene YTHDF2 and viral infectious disease.