In related studies, it was found that in the ALI mouse model, METTL3-m6A mediated the expression of apolipoprotein C3 (ApoC3) mRNA in macrophages and promoted the activation of NLRP3 inflammatory vesicles, which led to macrophage pyroptosis and the release of inflammatory factors such as IL-1β, thus exacerbating the lung injury (Pu et al., 2024). Here, NLRP3 is linked to acute respiratory distress syndrome.