CD4 and asthma: METTL3 was shown to be highly expressed in CD4+ T cells obtained from the peripheral blood of asthma patients, which may have been due to the fact that METTL3 synergizes with YTHDF2 to mediate a reduction of Foxp3 mRNA stability by m6A, leading to dysregulation of Treg/Th17 homeostasis and regulating inflammatory responses in asthma (Fan et al., 2022).