Another animal study indicated that in LPS-induced mouse Kupffer cells, METTL3/METTL14-m6A modification of TGF-β1 mRNA promoted the expressions of TGF-β1, IL-1β, and IL-6 as well as the development of hepatic fibrosis (Feng et al., 2021). Here, TGFB1 is linked to Hepatic fibrosis.