YTHDF1 gene expression was upregulated in human macrophages infected by syphilis, whereas YTHDF1 knockdown upregulated the expression of M1 markers (CD86 and iNOS) and downregulated M2 markers (CD206 and ARG1); during the course of infection, m6A-YTHDF1 promoted the inhibitory factor of the important macrophage inflammatory pathway JAK2/STAT3-mRNA translation, thus negatively regulating macrophage-associated inflammatory responses and the secretion of the inflammatory factor IL-1β (Li et al., 2022). Here, YTHDF1 is linked to syphilis.