WWP1 and Sepsis: Additional in vivo and in vitro experimental studies have shown that TYHDF1 is upregulated under sepsis environmental conditions and mediates m6A modification of WWP1 mRNA in macrophage cell line RAW264.7 cells, which promotes the translation of WWP1 and consequently inhibits apoptosis and the release of the IL-1β inflammatory factor via the WWP1/NLRP3/caspase-1 axis (Zhang S. et al., 2022).