NFKB1 and asthma: In the inflammatory response of macrophages in atherosclerosis, m6A-METTL14 directly acted on the p65 NF-κB pathway to regulate IL-6 transcription, which in turn induced macrophage M2 polarization (Zheng et al., 2022), which is similar to the mechanism by which YTHDF2 mediates macrophage effects on the inflammatory subtype of asthma; therefore, it would be worthwhile to further investigate whether this mechanism is synergistically accomplished by both factors.