Recent studies have shown that low METTL3 expression in the peripheral blood of Th2 asthma patients is correlated with disease severity, and further animal experiments confirmed that decreasing METTL3-m6A methylation activity regulated CD4+ T cell activity by increasing the stability of SOX5 mRNA in bronchial epithelial cells, which in turn upregulated GATA3/Th2 activity, inhibited T-bet/Th1 activity, and promoted the development of Th2 asthma (Chen et al., 2024). Here, METTL3 is linked to asthma.