In a mouse model of sepsis-associated acute lung injury (SI-ALI), NETs induced METTL3-m6A modification of GPX4 mRNA, which inhibited GPX4 expression by reducing GPX4 mRNA stability and promoted iron death in alveolar epithelial cells, while NETs specifically exacerbated iron death through the TLR9/MyD88/NF-kβ/METTL3-m6A/GPX4/ROS pathway to exacerbate iron death and contribute to the development of lung injury (Zhang et al., 2022). This evidence concerns the gene METTL3 and acute respiratory distress syndrome.