Another study of LPS-induced macrophages found that METTL3-m6A targeting of Irakm mRNA/TLR4 signaling in macrophages promoted macrophage activation (Tong et al., 2021) Recent m6A-seq sequencing of peripheral blood cells from children with allergic asthma revealed that METTL3 is lowly expressed in monocyte-derived macrophages from children with allergic asthma (Han et al., 2023). This evidence concerns the gene TLR4 and allergic asthma.