NFKB1 and asthma: Recent studies have confirmed that FTO, acting as an eraser, downregulated the m6A modification on IKBKB mRNA in a mouse asthma model, thereby enhancing its stability and leading to the upregulation of IKBKB expression, which effectively attenuated epithelial barrier damage in PM2.5-exposed cells by regulating NF-κB signaling (Xiong et al., 2024).