In a mouse model of knee osteoarthritis, extracellular vesicles inhibited the downregulation of NLRP3 expression activity via modification of NLRP3 mRNA by METTL3-m6A in macrophages and inhibited the secretion of IL-1β and IL-18 inflammatory factors and inflammatory responses (Zhou et al., 2022). The gene discussed is NLRP3; the disease is osteoarthritis, knee.