Animal studies revealed that METTL14 levels were upregulated in macrophages from ischemic stroke rats, and KAT3B expression was enhanced by m6A modification of KAT3B mRNA, whereas knockdown of the METTL14 gene promoted macrophage switching from M1 to M2 via KAT3B-STING signaling and further inhibited NLRP3 inflammatory vesicles in macrophages to decrease IL-1β levels and alleviate brain injury (Li et al., 2023). Here, EP300 is linked to ischemic stroke.