The JAK2/STAT3 signaling pathway in macrophages is an important target for allergic asthma development and is involved in important asthma pathological processes such as the activation of mast cells and the promotion of bronchial smooth muscle thickening and airway remodeling (Qu et al., 2022; Wang et al., 2022; Bai et al., 2023). The gene discussed is JAK2; the disease is asthma.