ACTA1 and metabolic dysfunction-associated steatohepatitis: Our RNA-seq data showed that, under standard diet or high-fat diet conditions, Fc(mML1)B3 suppressed the expression of genes related to this crosslinking, such as Eln, Lox, Loxl4, and Loxl1. Furthermore, α-SMA-positive cells in the liver, namely activated hepatic stellate cells, which play a crucial role in fibrosis associated with NASH,13 decreased under both diet conditions after treatment with both Fc(mML1)B3 and Fc, with a more pronounced decrease in the Fc(mML1)B3 group.