Moreover, when administered subcutaneously once a week, the Fc-based HGF mimetic demonstrated effectiveness in promoting the reduction of lipid accumulation, fibrosis, and macrophage aggregation in the liver of mice fed a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD), a diet that induces hepatic features similar to those observed in human NASH.34 Here, HGF is linked to metabolic dysfunction-associated steatohepatitis.