Our findings indicate that the more benign phenotype in LRRK2-associated parkinsonism may be driven by asyn-negative cases, A comparison of LRRK2-parkinsonism cases with asyn aggregates to sporadic cases with asyn aggregates is needed to determine the influence of the pathogenic variant itself on phenotype among those with asyn aggregates, and this analysis is underway in the PPMI cohort. The gene discussed is LRRK2; the disease is Parkinson disease.