LRRK2 and supranuclear palsy, progressive, 1: Other pathologies present in some individuals with LRRK2-associated parkinsonism who do not demonstrate evidence of asyn aggregates include tauopathy, with Alzheimer’s disease (AD) type tau (3R and 4R) predominating, but some demonstrate hyperphosphorylated tau resembling progressive supranuclear palsy (PSP), and less commonly TAR DNA-binding protein 43 (TDP43)3,7,8.