We undertook this study with the objectives of comparing among LRRK2-associated parkinsonism cases with and without evidence of asyn aggregates whether there are (1) differences in clinical features cross-sectionally and longitudinally (2) distinguishing features in available biofluid or imaging markers cross-sectionally and longitudinally (3) differences in prevalence of PD genetic risk. The gene discussed is LRRK2; the disease is Parkinsonism.