LRRK2 and Parkinson disease: In light of the differences in MDS-UPDRS II in the LRRK2-parkinsonim CSFasynSAA- vs CSFasynSAA+ cases, we next examined differences in LRRK2 CSFasynSAA- vs sPD CSFasynSAA+, as this analysis can provide insights as to whether the differences are unique to LRRK2 parkinsonism or are rather more a reflection of asyn aggregates status.