To survive inside the host during chronic infection, fungus must be able to adapt to adverse environment and microevolution could be the driving force of immune response and virulence change, such as the experiment of continuous coincubation of Candida glabrata with a murine macrophage cell line for over six months [12], which resulted in alteration of morphology with increased immunogenicity (TNF-α) and increased virulence (mouse infection model). Here, TNF is linked to infection.