For example, for diseases such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) that can underly non-AD MCI(Ciafone et al., 2020; Martinez-Horta and Kulisevsky, 2019), aggregated alpha synuclein could induce synaptic disturbances(Gcwensa et al., 2021; Trudler et al., 2021). The gene discussed is SNCA; the disease is Parkinson disease.