Compared to controls, individuals with prodromal AD showed lower levels of NPTX2 and higher levels of 14-3-3 epsilon (YWHAE), 14-3-3 eta (YWHAH), 14-3-3 zeta (YWHAZ), NEFL, NRGN, GAP43, Tumor protein D52 (TPD52), VAMP-associated protein A (VAPA) and Aldo-keto reductase family 1 member A1 (AKR1A1), and the levels of these proteins were typically also higher in prodromal AD compared to preclinical AD and non-AD MCI (Figure 2A, Supplementary table 1). Here, NPTX2 is linked to Alzheimer disease.