In preclinical AD, lower levels of calsyntenin-1 (CLSTN1), calsyntenin-3 (CLSTN3), secretogranin (SCG2), cell adhesion molecule 3 (CADM3) and neuronal cell adhesion molecule (NRCAM) were associated with lower delayed recall scores (Figure 4). This evidence concerns the gene CLSTN3 and Alzheimer disease.