Associations of synaptosomal-associated protein 25 (SNAP25) and neuromodulin (also called growth-associated protein 43, GAP43) with memory functioning depended on disease stage, with associations in early but not in later AD.(Pereira et al., 2020) Many additional synaptic proteins exist, for which it is largely unknown if they correlate with memory functioning in the early stages of AD before dementia onset. This evidence concerns the gene SNAP25 and Alzheimer disease.