These include “central dogma” and “mutation difference leading to disease.” For instance, chromatin translocation of the t (9;22) (q34; q11) (Philadelphia chromosome) comprising the ABL gene and the BCR gene, producing BCR-ABL oncogene is a famous fusion event driving chronic myeloid leukemia (CML). The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.