Alzheimer’s disease (AD) is a multifactorial disorder influenced by a variety of genetic and environmental factors.1 The disease is characterized by the accumulation of misfolded, insoluble protein aggregates, composed primarily of amyloid-β (Aβ) peptide (plaques) and phosphorylated tau protein (forming neurofibrillary tangles (NFT)) in the brain 2,3, which leads to the insidious onset and gradual disruption of cognitive and behavioral functions,3,4,5. This evidence concerns the gene MAPT and Alzheimer disease.