Other UBE2 enzymes, such as UBE2I, UBE2Q1, UBE2E1, and UBE2Z, display varied regulatory patterns in neurodegenerative diseases like frontotemporal dementia, suggesting the Ube2 family’s extensive influence on neurodegeneration, inflammation, and cellular stress responses69. This evidence concerns the gene UBE2Z and neurodegenerative disease.