TLR4 and asthma: LPS/endotoxin is a potent pneumotoxin that triggers neutrophilia and edema,(60) and intranasal and systemically administered LPS are used as models for septic lung injury.(61) Indeed, TLR4 inhibition using TAK-242 slightly reduced the pro-inflammatory responses of HBEC3-KT cells, principally the induction of IL6, which is a crucial acute phase response protein that regulates inflammation and impacts health/diseases, including asthma.(62–64) Thus, modulation of by GSLD and various inhibitors IL6 is noteworthy.