MTOR and chronic kidney disease: The increased expression of the mammalian target of rapamycin (mTOR) affected autophagy and apoptosis signaling in cells with aPKD1 gene mutation.1,7–9 In addition, many studies have shown the mechanisms by which cyclic adenosine monophosphate (cAMP) levels influence PKD.10–13 Oral administration of antioxidant agents such as DHA-enriched fish oils showed potential renoprotective effects in cats with chronic kidney disease related toPKD gene mutation.14