It is one of this breed’s most common feline genetic diseases, other than diabetes and feline lower urinary tract disease.3 This disease not only impacts the Persian breed but other breeds, including the Exotic Shorthair, British Shorthair, American Shorthair, Himalayan, Scottish fold, Ragdoll, Chartreaux, and Maine Coon breeds, may also be affected by this disease.4–6 The polycystin-1 (PKD1) gene mutation was indicated for 85% of human autosomal dominant polycystic kidney disease (ADPKD). The gene discussed is PKD1; the disease is hereditary disease.