In our study CD161 gene expression analysis was extended to RR-MS and SP-MS transcriptomics data, and MAIT cell frequency by flow cytometry was enriched by the detection of Vα7.2 on CD161high CD8+ T cells in novel cohorts of untreated PP-MS subjects and MS patients with other disease courses thus allowing comparisons among distinct forms of MS. This evidence concerns the gene CD8A and myeloid sarcoma.