A previous paper from our group described transcriptional down-regulation of CD161 and loss of circulating CD8+CD161high T cells in PP-MS but did not address disease specificity of the observation and neither clarified whether this reduction was due to the loss of MAIT cells in blood or rather to the downregulation of CD161, which may occur under chronic stimulation (18). Here, CD8A is linked to myeloid sarcoma.