Pursuant to current research, the HIGD gene family is induced expression by hypoxia-inducible factor-1α (HIF-1α) in hypoxic conditions, participates in the assembly of mitochondrial complexes, and regulates mitochondrial homeostasis, affect a range of physiological and pathological processes, and be a significant factor in numerous illnesses (particularly cardiovascular diseases, diabetes, and cancer). Here, HIF1A is linked to cancer.