According to the analysis of pan-cancer data downloaded from the TCGA database (Supplementary Table S2), HIGD1B was observed to be significantly upregulated in the tumor tissues of COAD, ESCA, HNSC, KIRC, LIHC, STAD, and THCA, but lowered in BRCA, KICH, LUAD, LUSC, and UCEC (Figures 1A, C). The gene discussed is HIGD1B; the disease is cancer.