CD4 and Sepsis: Functions as a ligand, Neutrophil strongly increased the activity of RETN-CAP1 to interact with the majority of receptor cells (CD4+ T cell, CD8+ T cell, NK cell, macrophage, megakaryocyte, B cell, DC, and plasma cell) in the sepsis group and lightly decreased the activity of ANXA1-FPR1 interact with CD4+ T cell (strong), GRN-SORT1 interact with macrophage (light), TNFSF13B-TNFRSF17 interact with plasma cell (light).