USP1 regulates monoUb FANCD2 Fanconi Anemia protein, promoting resistance to DNA cross‐linking chemotherapeutic agents [10]. USP1 deubiquitinates monoUb PCNA [10]. *USP1 inhibition promotes the degradation of ID1, suppressing the growth of AML cells [11]. The gene discussed is FANCD2; the disease is acute myeloid leukemia.