Usp15 KO compromises mHSC maintenance and reconstitution potential in vivo [5]. *USP15 stabilises FUS and safeguards genome integrity in HSC and LSC [5]. *USP15 stabilises KEAP1 and MDM2 to modulate redox and p53 signalling in AML cell [6]. *USP15 is overexpressed in hAML [5, 6] and differentially expressed in MDS [4]. Here, MDM2 is linked to acute myeloid leukemia.