*USP10 stabilises oncogenic FLT3‐ITD in AML [24]. *USP10 deubiquitinates and stabilises SKP2 enhancing the growth of CML xenografts in vivo [25]. *USP10 deubiquitinates and stabilises the tyrosine kinase SYK promoting the proliferation of SYK‐driven AML cells [26]. The gene discussed is SYK; the disease is acute myeloid leukemia.