SLC5A2 and gangrene: Severe ADRs were defined as hospitalizations potentially related to SGLT2 inhibitor ADRs, specifically those due to urinary tract/genital infections, ketosis including diabetic ketoacidosis (DKA), volume depletion including hyperosmolar hyperglycemic state (HHS), hypoglycemia, cerebral infarction, and gangrene with leg amputation.