PX‐478, a HIF‐1α inhibitor, has been shown to inhibit the protein expression level and transcriptional activity of HIF‐1α, thereby exhibiting effective antitumour activity in various tumours, including nonsmall cell lung cancer, glioma and pancreatic cancer.59, 60, 61. The gene discussed is HIF1A; the disease is familial pancreatic carcinoma.