Indeed, differential expression analysis comparing APS vs controls showed logFC values of 2.25 (P = 1.58e-05) for C3, 2.17 (P = 2.69e-06) for C4A, and 2.135 (P = 3.7e-06) for C4B (Supplementary Table S1). This evidence concerns the gene C4B and autoimmune polyendocrinopathy.