Among the TFBSs identified by BertSNR, EGR1 regulates POU5F1 expression in human lung cancer (Feng et al. 2019); GATA1 can replace POU5F1 to reprogram cells into pluripotency (Shu et al. 2015); STAT3 promotes POU5F1 to regulate cellular self-renewal (Yin et al. 2015); ELF3 affects transcription of the POU5F1 gene (Park et al. 2014); and SOX2 and POU5F1 are linked through the Oct4/Sox2 complex to mutually regulate transcription (Chew et al. 2005). The gene discussed is STAT3; the disease is lung cancer.