TP53 and neoplasm: TWIST1 is a transcription factor which promotes the MDM2-mediated degradation of p53, one of the main tumor suppressors, by interacting with its binding site on p53, known as “Twist-box.” A llama nanobody (VHH) shown to interfere with TWIST1: P 53 interaction by binding to p53 with moderate binding affinity was modelled by homology and then docked onto p53 (D’Agostino et al. 2022).