The level of circ‐SLC9A6 was positively correlated with the progression of NAFLD in patients (Figure 1B), which was consistent with findings observed in both wild‐type and leptin‐deficient obese (ob/ob) mice and a methionine‐choline‐deficient diet‐induced steatohepatitis model (Figure 1C,D). This evidence concerns the gene SLC9A6 and metabolic dysfunction-associated steatotic liver disease.