IPP and neoplasm: In preliminary experiments on NCI-H2228 cells, we verified that 100 nM NZ did not reduce the cholesterol synthesis in shTFEB cells (Supplemental Fig. S6A), but it increased the IPP synthesis (Supplemental Fig. 6B) and efflux (Supplemental Fig. 6C), the percentage of activated Vγ9Vδ2 T-lymphocytes (Supplemental Fig. 6D) and the tumor cell immuno-killing by Vγ9Vδ2 T-lymphocytes, both alone and in combination with PT (Supplemental Fig. 6E).