Intriguingly, in shTFEB tumors, the combination of NZ + PT significantly expanded the Vγ9Vδ2 T-lymphocytes and other anti-tumor populations as CD4+T-helper lymphocytes, NK cells and CD8+T-cytotoxic lymphocytes that were not detected in the TME of vehicle-treated shTFEB tumors, while it decreased Treg cells (Fig. 8D; Supplemental Fig. S11D), suggesting a reshaping toward a less immuno-suppressive TIME. Here, CD4 is linked to neoplasm.