The TIME of shTFEB tumors was more heterogeneous in composition upon PT treatment, including – among the differentially detected populations - anti-tumor (CD4+T-helper lymphocytes, Vγ9Vδ2 T-lymphocytes and natural killer - NK) cells, as well as pro-tumor (Treg and Th17 T-lymphocytes) cells (Fig. 8B). Here, CD4 is linked to neoplasm.