As proof of concept that TFEB is a controller of chemo- and immuno-resistance in NSCLC cells, we verified if the overexpression of the constitutively active TFEBS142A form in cells previously silenced for endogenous TFEB (ovTFEB; Fig. 5A) may rescue the phenotype produced by TFEB silencing. Here, TFEB is linked to non-small cell lung carcinoma.