According to a study on melanoma, the inflamed and non-inflamed subsets exhibited a comparable load of immunogenic antigens, while the latter cohorts were deficient in recruiting and activating Batf3-lineage DCs, the key cell type for the initial cross-priming of anti-tumor CD8+ T cells, which implied that any malfunction in the APM could potentially impact the context of the TIME [94]. The gene discussed is CD8A; the disease is melanoma.