TNF and rheumatoid arthritis: According to clinical investigation, YXB has positive effects on OA and RA, which can not only effectively relieve joint pain, but reduce the expression of patients’ serum C-reactive protein, interleukin-8 (IL-8), IL-6, IL-1, tumor necrosis factor-α(TNF-α), intercellular cell adhesion molecule-1(ICAM-1), and facilitate foster inflammation resolution[20, 21].In terms of animal experimental, it has been proven that YXB can intervene in RA by inhibiting angiogenesis through suppressing LOX/Ras/Raf-1 signaling[22].