In addition, FLI-1 can also regulate the expression of leukaemia inhibitory factor (LIF) and its receptor, trappin-2, adipsin, antimicrobial peptide LL-37, cathepsin L (CTSL), EPCR, neuropilin 1 (NRP1), chemerin and calponin 1 (CNN1) in ECs, further affecting SSc lesions[26, 36, 48–54] (Table 2). The gene discussed is CNN1; the disease is systemic sclerosis.