Zhang et al. compared SLE model mice (MRL/lpr mice) with FLI-1 heterozygote mice and found that the infiltration of inflammatory cells into the kidneys of MRL/lpr mice was significantly increased and that the level of inflammatory cell infiltration was correlated with the expression of inflammatory chemokines (CCL2, CCL3, CCL4, and CCL5) in the kidneys [59]. This evidence concerns the gene FLI1 and systemic lupus erythematosus.