Overexpressing FLI-1 in haematopoietic progenitor cells inhibits CD4( +) T cells differentiation and enhances CD8( +) T cells development, which may eventually lead to pre-T cell lymphoblastic leukaemia/lymphoma in transgenic mice; downregulating the expression of FLI-1 in fibroblasts may lead to SSc; and a lack of FLI-1 in megakaryocytic progenitor cells results in a defect in megakaryopoiesis, which can lead to Jacobsen or Paris-Trousseau syndrome [9]. The gene discussed is FLI1; the disease is systemic sclerosis.