In this metabolic process, pyruvate is converted to lactate by LDHA, which is also deregulated in CCA in a GLUT5-expression-dependent manner, indicating that elevated GLUT5 levels result in increased lactate production in cancer cells (Suwannakul et al. 2022; Cai et al. 2013). The gene discussed is SLC2A5; the disease is cholangiocarcinoma.