Specifically, KHK-A promotes breast cancer metastasis by facilitating the nuclear translocation and subsequent phosphorylation of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH) at Ser25, which recruits snail family transcriptional repressor 2 (SNAI2) to repress cadherin 1 (CDH1) expression, a key step in epithelial-mesenchymal transition (EMT) (Kim et al. 2020). Here, CDH1 is linked to breast cancer.