ALOX12 and cancer: Moreover, fructose is implicated in promoting cancer cell invasion and migration through the upregulation of lipoxygenase-12 (12-LOX) and the production of 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE), a key fatty acid in cell membrane function and signaling (Jiang et al. 2016b).