ERBB2 and breast carcinoma: Case #40 was a breast cancer originally classified as ISH group 1 with HER2/CEP17 ratio of 3.06 and an average of HER2 copy number of 11.12, classified by IA as ISH group 3 with HER2/CEP17 ratio of 1.80 and an average of HER2 copy number of 6.10.