Subsequently, mutations in the tumor suppressor genes TSC1 and TSC2 lead to the overactivation of mTORC1 signaling, an important target of PI3K–Akt signaling.215 The transcription factor Myc is a significant downstream target of the Ras-ERK signal as well as numerous other pathways, and it is often amplified or overexpressed in cancer. Here, AKT1 is linked to cancer.