The aberrant activation of the Ras-MAPK signaling pathway has a bearing on many diseases, including cancer and neurodegenerative diseases.132,133 Moreover, this pathway also interacts with other signaling pathways such as PI3K–Akt, Janus kinase (JAK)-signal transducers and activators of transcription (STAT), etc., jointly regulating processes such as cell growth, proliferation, and differentiation. This evidence concerns the gene AKT1 and cancer.