According to reports, the expression level and activity of the main cardiac subtype CaMKIIδ are unregulated in human heart failure.244,245 Chronic overactivation of CaMKII can lead to several other pathological symptoms, including cardiac hypertrophy,246 diastolic and systolic dysfunction,247,248 arrhythmia,249,250, and ischemia/reperfusion injury.251,252 Different PTMs of CaMKII lead heart disease through different pathological mechanisms. The gene discussed is CAMK2G; the disease is heart failure.