CD8A and neoplasm: To elucidate the relationship between the anti-tumor effect of Aldh1a1 knockdown and CD8+ T cells, shAldh1a1 cells were injected into immunocompetent mice, and CD8α monoclonal neutralizing antibody (mAb) or immunoglobulin G (IgG) isotype Ctrl (IgG2b) was administered to the mice (Supplementary Fig. S9A).