Thus, the main purpose of this study was to investigate the effects of 8 weeks of low‐volume HIIT with low compression (LC) versus low‐volume HIIT with high compression (HC), with or without BBR, on the regulation of noncoding RNAs H19, NLRP3, IL‐1β, hs‐CRP, and insulin resistance markers in middle‐aged men with overweight or obesity and prediabetes. This evidence concerns the gene H19 and obesity due to melanocortin 4 receptor deficiency.