SLC12A5 and tuberous sclerosis: The ratio of KCC2pThr906 to total KCC2 (n = 6 western blot and N = 4 MCD: two FCD, one TSC and one HMG) was significantly decreased in the lysate following treatment with BYL719 (1.12 ± 0.04 versus 0.90 ± 0.08, P = 0.026), everolimus (1.12 ± 0.04 versus 0.77 ± 0.09 versus, P < 0.001) and rapamycin (1.12 ± 0.04 versus 0.64 ± 0.06, P < 0.001) respectively compared with untreated (Fig. 4B).