This is supported by studies showing loss of GADD34 enhances survival and delays neurodegeneration in various ALS model systems, and loss of PERK accelerates disease progression, while pharmacologically upregulating heat shock and unfolded protein response pathways significantly improves outcomes in ALS models (34,35,86,101–103). The gene discussed is PPP1R15A; the disease is amyotrophic lateral sclerosis.