MDA levels:Controls: 0.56 ± 0.25 nmol/mL;Infertile men with varicocele and normal SA: 1.43 ± 1.2 nmol/mL(P<0.05 versus controls);Infertile men with varicocele and abnormal SA: 1.63 ± 1.38 nmol/mL(P<0.05 versus controls);GPx and CAT activities were decreased in both groups with varicocele, and SOD activity was decreased only in infertile men with varicocele and abnormal SA when compared to controls(P<0.05). The gene discussed is SOD1; the disease is varicocele.