A higher risk of death was also observed in the third tertile of T2D duration (HR, 1.75; 95% CI, 1.12-2.71) and in those taking diabetes medication (insulin HR, 2.01; 95% CI, 1.25-3.23; and oral medications HR, 1.40; 95 CI, 1.03-1.91). Here, INS is linked to type 2 diabetes mellitus.