INS and bone fracture: Fully adjusted Cox regression models found an increased fracture risk in women treated with insulin, compared with controls, for any fracture (HR, 1.71; 95% CI, 1.16-2.54) and MOF (HR, 1.89; 95% CI, 1.24-2.87) but not for hip fracture (HR, 1.14; 95% CI, 0.42-3.08).