In addition, inhibition of the splicing pathway of Aβ prevents the β-amyloid precursor protein from splicing into Aβ through the amyloidogenic pathway, thus preventing it from generating and accumulating amyloid plaques (Ahmad et al. 2015), activating nerve conduction pathways, increasing the acetylcholine level, reducing the acetylcholinesterase level to prevent N-methyl-D-aspartate receptors from opening ion channels, and causing excessive calcium damage in neurons (Bagheri et al. 2012). This evidence concerns the gene ACHE and amyloidosis.