However, due to the aforementioned limitations of the present study and the complex pathophysiology of CM, further studies, preferably with a multicenter design and larger sample size, are needed to explore the genetic architecture of migraine chronification and to investigate the gene-gene and gene-environment interactions of TRPV1 SNPs on the risk of transformation from EM to CM. The gene discussed is TRPV1; the disease is cutaneous mastocytosis.