The interest in investigating the involvement of TRPV1 channels in migraine stems primarily from their localization on meningeal nociceptors and their ability to respond to various endogenous and exogenous stimuli involved in migraine pathogenesis, including capsaicin, endocannabinoids, endovanilloids, prostaglandins, nerve growth factors, and lipoxygenase metabolites [28, 29]. The gene discussed is TRPV1; the disease is migraine disorder.