In particular, it has been reported that inhibition of TGFβ signaling increases CXCL9/10 in cancer-associated fibroblast subset, enhancing the infiltration of antigenic CD8 T lymphocyte in tumors [65], and CCL5 is known to induce apoptosis of CD8 T lymphocyte due to regulatory T lymphocyte by utilizing TGFβ as an effector [66]. This evidence concerns the gene CD8A and cancer.