As shown in Fig. 5, CD8Cre-CD27fl (CD8-specific CD27 KO) did not change the frequencies of CD4 + , CD8 + , CD4 + Foxp3 + T cell subsets or CD19 + B cells in CD45 + immune cells in tumor-infiltrated lungs, while global CD70 KO significantly reduced the frequency of CD4 + Foxp3 + Treg cells, which is consistent with a previous report [6]. The gene discussed is CD4; the disease is neoplasm.