In contrast, the CD27-CD70 axis was shown to be critical for mediating interaction between conventional type 1 dendritic cells (cDC1s) and adoptively transferred tumor antigen-specific T cells, promoting the expansion and antitumor efficacy of adoptively transferred CD8 + T cells [8], yet it appeared to be dispensable for the antitumor efficacy of neoantigen vaccine and generation of neoantigen-specific CX3CR1 + CD8 + T cells [9]. The gene discussed is CD8A; the disease is neoplasm.