We have developed a novel adoptive dendritic cell, M-DCTNF, which expresses membrane-anchored Muc1 monoclonal Ab, scFv, to target a broad range of breast cancers and produces a single tumoricidal factor-TNFα locally to kill cancer cells in combination with the IAP antagonist, SM-164, which degrades IAP proteins [16]. The gene discussed is TNF; the disease is breast cancer.