TIGIT’s role as part of a posited dysfunctional immune circuit involving T cells and macrophages leading to more advanced disease in RCC was further confirmed in this study through flow cytometry analysis of TIGIT expression on terminally exhausted CD8+ T cells paired with expression of CD155, a TIGIT ligand, on M2-like, immunosuppressive macrophages. This evidence concerns the gene CD8A and renal cell carcinoma.