Among metastases only, there was a negative correlation with PD-1 expression (r = −0.524, p = 0.048), and among all tumor samples (primary tumors and metastases), there were negative correlations between TIGIT and PD-1 (r = −0.301, p = 0.032), and TIGIT and LAG3 (r = −0.394, p = 0.005) (Fig. 4A, B and Supp. Here, LAG3 is linked to neoplasm.