Furthermore, as observed in the tumor-infiltrated T-cells of BsTE:OT-1 T-cells (Fig. 1E), the tumor-infiltrating lymphocyte analysis of the WT MC38-bearing mice showed that BsTE:T treatment enhanced the accumulation of CD44high CD62Llow effector memory CD8+ T-cells in the tumor tissue compared with that of central memory CD8+ T-cells (CD44high CD62Lhigh), whereas control and T-cell-treated mice did not show any significant increase in the level of CD8+ T-cell infiltration (Fig. 4E, Supplementary Fig. 4A). Here, CD8A is linked to neoplasm.