Studies from our laboratoryhave shown that the overexpressionof Cx43 in human TNBC breast cancer cells favors the mesenchymal toepithelial transition (MET), reducing cell proliferation, invasiveness,xenograft tumor onset and growth, metastasis, and restoring cellulardifferentiation capacity, thus suggesting that Cx43 has tumor suppressiveroles. The gene discussed is GJA1; the disease is breast cancer.