Inthis article, we explored the progressivetransformation ofbiomechanical properties of cancer cells across the spectrum of metastaticpotential derived from the same cell line by regulating Cx43 expression.Some studies have shown that aggressive cancer cells can potentiallyadaptively soften, disseminate from their microenvironment, elongateto squeeze through capillaries, and metastasize into distant bodysites, forming life-threatening metastatic foci.28−55 Cell biomechanics plays a significant role in cancerinitiation and progression. Here, GJA1 is linked to cancer.